New tetramethylthiepinium (TMTI) for copper-free click chemistry
M King, R Baati, A Wagner
Index: King, Mathias; Baati, Rachid; Wagner, Alain Chemical Communications, 2012 , vol. 48, # 74 p. 9308 - 9309
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Citation Number: 7
Abstract
A new derivative of the strained 3, 3, 6, 6-tetramethylthiacycloheptyne (TMTH) bearing a functional handle is reported. Following an optimized synthesis, the handle was introduced by mild alkylation of the sulphur atom. The resulting functionalized strained 4, 5-didehydro-3, 3, 6, 6-tetramethyl-2, 3, 6, 7-tetrahydrothiepinium (TMTI) proved to be stable and underwent extremely fast [3+ 2] cycloaddition reaction with benzyl azide in both organic and aqueous ...
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