Organic letters

Continuous multiple liquid–liquid separation: Diazotization of amino acids in flow

DX Hu, M O'Brien, SV Ley

Index: Hu, Dennis X.; O'Brien, Matthew; Ley, Steven V. Organic Letters, 2012 , vol. 14, # 16 p. 4246 - 4249

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Citation Number: 53

Abstract

A second-generation laboratory-scale, modular liquid–liquid separation device based on computer-controlled high-pressure pumps and a high-resolution digital camera has been invented. The diazotization of amino acids to produce valuable chiral hydroxyacids is demonstrated in flow for the first time. The use of a triple-separator system in conjuction with the developed diazotization process allows the safe and efficient production and ...

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