Novel synthesis of [1??11C] γ??vinyl?螃摸?aminobutyric acid ([1–11C] GVG) for pharmacokinetic studies of addiction treatment

…, YS Ding, AR Studenov, MR Gerasimov…

Index: Zhang, Zongren; Ding, Yu-Shin; Studenov, Andrei R.; Gerasimov, Madina R.; Ferrieri, Richard A. Journal of Labelled Compounds and Radiopharmaceuticals, 2002 , vol. 45, # 3 p. 199 - 211

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Abstract

Abstract γ-Vinyl-γ-aminobutyric acid (GVG, Vigabatrin®), a suicide inhibitor of GABA- transaminase (GABA-T), has been suggested as a new drug for the treatment of substance abuse. In order to better understand its pharmacokinetics and potential side effects, we have developed a radiosynthesis of carbon-11 (t 1/2= 20 min) labeled GVG for positron emission tomographic (PET) studies. We report here a novel synthetic strategy to prepare the ...

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