6, 7-Dimethoxy-3, 4-dihydroisoquinolin-1 (2H)-ylidenoacetonitrile in some fusion reactions

AA Afon'kin, ML Kostrikin, AE Shumeiko…

Index: Afon'kin; Kostrikin; Shumeiko; Popov Russian Journal of Organic Chemistry, 2011 , vol. 47, # 5 p. 731 - 745

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Abstract

Abstract 6, 7-Dimethoxy-3, 4-dihydroisoquinolin-1-ylacetonitrile in the enamine form readily reacts with acyl iso (thio) cyanates affording in high yields 1, 2-fused oxo-and thioxodihydropyrimidoisoquinolines and thiouracyloisoquinolines. The reaction of the enamine with primary amines of diverse classes in the presence of 2 equiv of formaldehyde resulted in 1, 2-fused N-substituted tetrahydropyrimidinoisoquinolines whose yields ...