Iridium-catalyzed annulation of N-arylcarbamoyl chlorides with internal alkynes.

Tomohiro Iwai, Tetsuaki Fujihara, Jun Terao, Yasushi Tsuji

Index: J. Am. Chem. Soc. 132(28) , 9602-3, (2010)

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Abstract

An iridium complex successfully catalyzed the annulation of various N-arylcarbamoyl chlorides with internal alkynes to afford 2-quinolones in good to excellent yields. The present reaction is widely applicable to substrates with various functionalities. An amide-iridacycle complex was isolated, and it is likely that such an iridacycle species is a key intermediate in the catalytic reaction.