Synthesis and adrenocortical-inhibiting activity of substituted 2, 2-diphenethylamines

WA Zuccarello, B Blank, GJ Frishmuth…

Index: Zuccarello,W.A. et al. Journal of Medicinal Chemistry, 1969 , vol. 12, # 1 p. 9 - 15

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Citation Number: 4

Abstract

The byiithe& atid adrenal-inhibitory effects of a series of substituted 2, 2-diphenethylamines are described. Nost of the analogs appear to suppress adrenal steroidogenesis by inhibition of the 11-hydroxylation reaction. The introduction of methyl at C-2 of the aliphatic side chain of 2 appears to inhibit enzymatic reactions occurring early in the biobyiithetic pathway, while the introduction of methyl at C-1 of 1 is followed by a highly selective inhibition of ...