Tetrahedron Letters

Molecular sieve mediated decarboxylative Mannich and aldol reactions of β-ketoacids

F Zhong, C Jiang, W Yao, LW Xu, Y Lu

Index: Zhong, Fangrui; Jiang, Chunhui; Yao, Weijun; Xu, Li-Wen; Lu, Yixin Tetrahedron Letters, 2013 , vol. 54, # 32 p. 4333 - 4336

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Citation Number: 12

Abstract

A molecular sieve mediated decarboxylative Mannich reaction of β-ketoacids with sulfonyl imines is reported; this protocol leads to an efficient preparation of synthetically useful β- amino ketones. An analogous molecular sieve promoted decarboxylative aldol reaction between β-ketoacids and isatins is also described, which affords bioactive 3-substituted-3- hydroxy-oxindoles in excellent yields.