One-pot synthesis of isoquinoline and related compounds via Cu-mediated tandem cross-coupling and cyclization

S Dhara, R Singha, Y Nuree, JK Ray

Index: Dhara, Shubhendu; Singha, Raju; Nuree, Yasin; Ray, Jayanta K. Tetrahedron Letters, 2014 , vol. 55, # 4 p. 795 - 798

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Citation Number: 10

Abstract

Abstract One-pot synthetic strategy has been developed to access isoquinolines and its analogs via Cu-mediated tandem cross-coupling and cyclization in good yields under mild reaction conditions. A mixture of suitably substituted α-bromoaldehyde, terminal alkyne, and aq NH 3 in CuI/1, 10-phenanathroline catalytic system afforded the 3-substituted isoquinoline regio-selectively in good to excellent yields.