Electrophoresis 2012-10-01

Rapid screening and determination of 4-chloroamphetamine in saliva by paper spray-mass spectrometry and capillary electrophoresis-mass spectrometry.

Chih-Sheng Jhang, Hsun Lee, Yi-San He, Ju-Tsung Liu, Cheng-Huang Lin

Index: Electrophoresis 33(19-20) , 3073-8, (2012)

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Abstract

A novel drug-screening system, consisting of paper spray-MS (PS-MS) and a CE-ESI-MS method was developed. This system can be easily switched either to PS-MS for rapidly screening samples or to the traditional CE-ESI-MS method for separation and to obtain detailed mass spectral information, while sharing the same mass spectrometer. In the former case, when a sharp (15°-tip) chromatography paper was used, the optimized distance from the paper tip to the mass inlet was 7.7 mm, whereas the optimized distance for the CE-ESI tip was ∼13.5 mm. Using 4-chloroamphetamine as a model compound, the LODs for PS-MS and CE-ESI-MS were determined to ∼0.1 and 0.25 ppm, respectively. Comparisons of results obtained using PS-MS and CE-ESI-MS and the experimental conditions are described.© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Related Compounds

  • UNII:YIJ78M8D5...

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