Current Drug Metabolism 2013-03-01

A review on noscapine, and its impact on heme metabolism.

Harpal Singh, Prashant Singh, Kamlesh Kumari, Ankush Chandra, Sujata K Dass, Ramesh Chandra

Index: Curr. Drug Metab. 14(3) , 351-60, (2013)

Full Text: HTML

Abstract

This review introduces the Noscapine, which is being used as an antitussive drug for a long time has been recently discovered as a novel tubulin-binding, anti-angiogenic anticancer drug that causes cell cycle arrest and induces apoptosis in cancer cells both in vitro as well as in vivo. Noscapine is a multifunctional molecule i.e. it possesses various functional moieties. We maneuvered various amenable sites and have synthesized analogs, which might prove to be more efficacious and less cytotoxic. Moreover, development of oral controlled release anticancer formulation of noscapine is severely hampered due to short biological half-life (<2-h), poor absorption, low aqueous solubility, and extensive first pass metabolism, thereby requiring large doses for effective treatment.

Related Compounds

  • Noscapine

Related Articles:

Determinants of increased opioid-related mortality in the United States and Canada, 1990-2013: a systematic review.

2014-08-01

[Am. J. Public Health 104(8) , e32-42, (2014)]

Adlumiceine methyl ester, a new alkaloid from Fumaria vaillantii.

2014-12-01

[J. Asian Nat. Prod. Res. 16(12) , 1148-52, (2014)]

Peloruside, laulimalide, and noscapine interactions with beta-tubulin.

2012-11-01

[Pharm. Res. 29(11) , 2985-93, (2012)]

The anti-cancer activity of noscapine: a review.

2009-01-01

[Recent Pat. Anticancer. Drug Discov. 4(1) , 92-7, (2009)]

Implications of nanoscale based drug delivery systems in delivery and targeting tubulin binding agent, noscapine in cancer cells.

2012-12-01

[Curr. Drug Metab. 13(10) , 1476-83, (2012)]

More Articles...