Design and synthesis of xanthine analogues as potent and selective PDE5 inhibitors

…, AW Stamford, WJ Greenlee, J Skell, S Kurowski…

Index: Wang, Yuguang; Chackalamannil, Samuel; Hu, Zhiyong; Boyle, Craig D.; Lankin, Claire M.; Xia, Yan; Xu, Ruo; Asberom, Theodros; Pissarnitski, Dmitri; Stamford, Andrew W.; Greenlee, William J.; Skell, Jeffrey; Kurowski, Stanley; Vemulapalli, Subbarao; Palamanda, Jairam; Chintala, Madhu; Wu, Ping; Myers, Joyce; Wang, Peng Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 21 p. 3149 - 3152

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Citation Number: 26

Abstract

Download PDF Opens in a new window. Article suggestions will be shown in a dialog on return to ScienceDirect. ... Please enable JavaScript to use all the features on this page. ... We have discovered potent and selective xanthine PDE5 inhibitors. Compound 25 (PDE5 IC 50 =0.6 nM, PDE6/PDE5=101) demonstrated similar functional efficacy and PK profile to Sildenafil (PDE5 IC 50 =3.5 nM, PDE6/PDE5=7). ... We have discovered potent and selective xanthine ...