The Journal of organic chemistry

High-throughput five minute microwave accelerated glycosylation approach to the synthesis of nucleoside libraries

BC Bookser, NB Raffaele

Index: Bookser, Brett C.; Raffaele, Nicholas B. Journal of Organic Chemistry, 2007 , vol. 72, # 1 p. 173 - 179

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Citation Number: 45

Abstract

The Vorbrüggen glycosylation reaction was adapted into a one-step 5 min/130° C microwave assisted reaction. Triethanolamine in acetontrile containing 2% water was determined to be optimal for the neutralization of trimethylsilyl triflate allowing for direct MPLC purification of the reaction mixture. When coupled with a NH3/methanol deprotection reaction, a high-throughput method of nucleoside library synthesis was enabled. The ...