The synthesis and biological evaluation of novel Danshensu–cysteine analog conjugates as cardiovascular-protective agents

…, P Zhou, X Liu, L Pan, H Xin, YZ Zhu, Y Wang

Index: Jia, Yaoling; Zhou, Pengfei; Wang, Yang; Dong, Xiaoyi; Liu, Xinhua; Pan, Lilong; Xin, Hong; Zhu, Yi Zhun European Journal of Medicinal Chemistry, 2012 , vol. 55, p. 176 - 187,12

Full Text: HTML

Citation Number: 18

Abstract

A series of novel amide and thioester conjugates between Danshensu and cysteine derivatives have been designed and synthesized based on the strategy of “medicinal chemical hybridization”. Pharmacological evaluation indicated that the amide conjugates 3a/4a/17a and thioester conjugates 6a–d exhibited obvious protective effects on H2O2- induced human umbilical vein endothelial cells (HUVECs). Pretreated with these ...

Related Articles:

Enzymatic synthesis of S-substituted L-cysteines with tryptophan synthase of Escherichia coli

[Esaki, Nobuyoshi; Tanaka, Hidehiko; Miles, Edith Wilson; Soda, Kenji Agricultural and Biological Chemistry, 1983 , vol. 47, # 12 p. 2861 - 2864]

S-Carboxymethylcysteine synthase from Escherichia coli

[Agricultural and Biological Chemistry, , vol. 53, # 9 p. 2481 - 2487]

Two new procedures for the introduction of benzyl-type protecting groups for thiols

[Tetrahedron Letters, , vol. 35, # 11 p. 1631 - 1634]

Selective acid hydrolysis of 2, 4, 6-trimethylbenzyl esters and its application in peptide synthesis

[Australian Journal of Chemistry, , vol. 19, p. 1511 - 1518]

Synthesis of a new fluorogenic substrate for cystine aminopeptidase.

[Chemical and pharmaceutical bulletin, , vol. 30, # 4 p. 1485 - 1487]

More Articles...