Inhibition of HIV-1 integrase-catalysed reaction by new DNA minor groove ligands: the oligo-1, 3-thiazolecarboxamide derivatives

…, R Bayandin, S Litvak, L Tarrago-Litvak…

Index: Ryabinin, Vladimir A.; Sinyakov, Alexander N.; De Soultrait, Vaea Richard; Caumont, Anne; Parissi, Vincent; Zakharova, Olga D.; Vasyutina, Elena L.; Yurchenko, Ekaterina; Bayandin, Roman; Litvak, Simon; Tarrago-Litvak, Laura; Nevinsky, Georgy A. European Journal of Medicinal Chemistry, 2000 , vol. 35, # 11 p. 989 - 1000

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Citation Number: 23

Abstract

Human immunodeficiency virus type 1 (HIV-1) integrase (IN) is an essential enzyme in the life cycle of the retrovirus, responsible for catalysing the insertion of the viral genome into the host cell chromosome. For this reason it provides an attractive target for antiviral drug design. We synthesized a series of novel thiazole (Tz)-containing oligopeptides (TCOs; oligo- 1, 3-thiazolecarboxamides), specifically interacting within the minor groove of DNA. The ...

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