Organic Letters 2002-01-24

A general and mild copper-catalyzed arylation of diethyl malonate.

Edward J Hennessy, Stephen L Buchwald

Index: Org. Lett. 4(2) , 269-72, (2002)

Full Text: HTML

Abstract

[reaction: see text] A general method for the synthesis of alpha-aryl malonates is described. The coupling of an aryl iodide and diethyl malonate in the presence of Cs(2)CO(3) and catalytic amounts of copper(I) iodide and 2-phenylphenol affords the alpha-aryl malonate in good to excellent yields. The mild reaction conditions and high levels of functional group compatibility make this an attractive synthetic alternative to previous methods.

Related Compounds

  • Diethyl malonate
  • diethylmalonic aci...

Related Articles:

Design, synthesis and structure-activity relationship studies of novel and diverse cyclooxygenase-2 inhibitors as anti-inflammatory drugs.

2014-12-01

[J. Enzyme Inhib. Med. Chem. 29(6) , 846-67, (2014)]

Identification of olfactory receptor neurons in Uraba lugens (Lepidoptera: Nolidae) and its implications for host range.

2015-07-01

[J. Insect Physiol. 78 , 33-46, (2015)]

Ring expansion reactions of 4-amino-1,1-dioxo-[1,2,3,5]-thiatriazoles.

2007-02-07

[Org. Biomol. Chem. 5(3) , 472-7, (2007)]

Intramolecular Hydrogen Bonding and Linear Pentapyrrole Conformation.

2014-08-01

[Monatsh. Chem 145(7) , 1117-1135, (2014)]

Room-temperature copper-catalyzed alpha-arylation of malonates.

2007-08-16

[Org. Lett. 9(17) , 3469-72, (2007)]

More Articles...