Journal of Clinical Psychopharmacology 2000-06-01

Single-dose pharmacokinetics of methylphenidate in CYP2D6 extensive and poor metabolizers.

C L DeVane, J S Markowitz, S W Carson, D W Boulton, H S Gill, Z Nahas, S C Risch

Index: J. Clin. Psychopharmacol. 20(3) , 347-9, (2000)

Full Text: HTML

Abstract

Six adults phenotyped as either extensive (N = 4) or poor (N = 2) metabolizers for cytochrome P450 (CYP) 2D6 were given a 10-mg oral dose of methylphenidate (MPH) on two separate occasions with and without quinidine, a potent CYP2D6 inhibitor. Quinidine had no significant effect on the pharmacokinetics of either MPH or ritalinic acid, its major metabolite, in either group of CYP2D6 metabolizers. These data suggest a lack of involvement of CYP2D6 in the metabolism of MPH. Drugs that are inhibitors of CYP2D6 when taken concurrently with MPH should not affect its plasma concentration.

Related Compounds

  • Ritalinic acid
  • alpha-Phenyl-2-pip...

Related Articles:

Determination of amphetamine and methylphenidate in exhaled breath of patients undergoing attention-deficit/hyperactivity disorder treatment.

2014-08-01

[Ther. Drug Monit. 36(4) , 528-34, (2014)]

Pharmacological Cognitive Enhancement in Healthy Individuals: A Compensation for Cognitive Deficits or a Question of Personality?

2015-01-01

[PLoS ONE 10 , e0129805, (2015)]

Potential trends in Attention Deficit Hyperactivity Disorder (ADHD) drug use on a college campus: wastewater analysis of amphetamine and ritalinic acid.

2013-04-15

[Sci. Total Environ. 450-451 , 242-9, (2013)]

A safer methylation procedure with boron trifluoride-methanol reagent for gas chromatographic analysis of ritalinic acid in urine.

1992-01-01

[J. Pharm. Biomed. Anal. 10 , 187, (1992)]

Detection of the novel metabolite ethylphenidate after methylphenidate overdose with alcohol coingestion.

1999-08-01

[J. Clin. Psychopharmacol. 19(4) , 362-6, (1999)]

More Articles...