Tetrahedron letters

Novel formation of 9, 18-diformyl-5, 6, 14, 17-tetrahydro-8, 17-epoxy-6H, 15H-[1, 5] diazocino [2, 1,-a: 6, 5-a′] diisoquinolines from (3, 4-dihydroisoquinolinyl-1) …

K Nagarajan, PJ Rodrigues, K Go, R Parthasarathy

Index: Nagarajan, Kuppuswamy; Rodrigues, Patrick J.; Go, Kuantee; Parthasarathy, Rengachary Tetrahedron Letters, 1992 , vol. 33, # 40 p. 6011 - 6014

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Citation Number: 4

Abstract

We wish to report the formation of interesting title compounds from the dialdehydes & which became available to us along with the monoaldehydes 2 from 1-methyl-3,4-dihydro- isoquinolines by a Vilsmeier reactionl. Our objective was the construction of the IF&iso- quino[2,1-b](2,7]naphthyridin -8-one ring system :, present in the Alangium alkaloids2 by means of a Hantzsch-type pyridine synthesis from 2 or & Reaction of 2 (R=R,=H) with methyl acetoacetate and ammonia ...

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