Journal of the American Chemical Society

Reductive cyclization of amino α-keto esters. A general method for the synthesis of nitrogen-heterocyclics having fused five-and six-membered rings

NJ Leonard, JH Boyer

Index: Leonard; Boyer Journal of the American Chemical Society, 1950 , vol. 72, p. 2980,2984

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Citation Number: 27

Abstract

Summary A series of 1-nitro-1-methylethyl alkyl malonic esters has been prepared by condensing 2-chloro-2-nitropropane with the sodium salt of the appropriate monoalkyl malonic ester. Catalytic hydrogenation of a representative of the series, 1-nitro-1-methylethyl ethyl malonic ester, resulted in cleavage to ethyl malonic ester. A typical member of the series, l-nitro-lmethylethyl methyl malonic ester, has been converted to the corresponding ...

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