Journal of the American Chemical Society

The Synthesis of Some 6-N-Substituted Amido Derivatives of 4, 6-Diaminoquinaldine and a Study of their in vitro Antibacterial Activity1, 2

CT Peng, TC Daniels

Index: Peng; Daniels Journal of the American Chemical Society, 1956 , vol. 78, p. 3703,3707

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Citation Number: 12

Abstract

The antibacterial activity reported for Surfen (bis-4-amin0-2-methyl-G-quinolylurea)~ and its low toxicity for tissues prompted an interest in the preparation of related derivatives for study as antibacterial agents. According to recent biochemical studies on the mode of action of s~ ramin,~ Antrycidej and other trypanocidal agents, o the activity does not depend upon the symmetry or the bismolecular character of the active compound. The Surfen-type ...