The Journal of Organic Chemistry

Potential Cancerocidal Agents. I. The Aromatic System of Podophyllotoxin (Part A) 1, 2

GR PETTIT, DS Alkalay

Index: Pettit,G.R.; Alkalay,D.S. Journal of Organic Chemistry, 1960 , vol. 25, p. 1363 - 1365

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Citation Number: 6

Abstract

The extended (1820-1942) appearance of podophyllum, the dried roots and rhizomes of certain Podophyllum species, in the US Pharmacopoeia was due to its early popularity in this country as a cathartic and cholagogue. Although podophyllum had received some application in early American medicine as a remedy for cancer, it was not until recently that the natural product was shown to be an effective antimitotic agent and actually useful in ...