Journal of Photochemistry and Photobiology B: Biology 2002-08-01

Photophysical and photosensitizing properties of selected cyanines.

Kawser Kassab

Index: J. Photochem. Photobiol. B, Biol. 68(1) , 15-22, (2002)

Full Text: HTML

Abstract

The present work has been carried out to obtain detailed information about the photophysical and photobiological properties of selected cyanines, in view of their possible use as photosensitizing agents. All the cyanines studied by us except CY-IV (3,3'-diethyl-4,4'-oxacarbocyanine), expressed an accelerated photobleaching in aqueous medium, a poor generation of singlet oxygen, and a relative weak photosensitizing activity towards albumin. On the cellular level, all cyanines exhibited a significant phototoxicity towards Balb/c 3T3 cells, upon irradiation with a total fluence of 30 J/cm(2). CY-III (3,3'-diethylcarbothiocayanine iodide) and CY-II (1,1'-diethyl-4,4'-carbocyanine iodide) appear to be promising photosensitizers, in spite of previous reports on the inefficiency of the former cyanine, and the rapid photobleaching of the latter compound.Copyright 2002 Elsevier Science B.V.

Related Compounds

  • 3,3'-Diethyloxadic...

Related Articles:

Mitochondrial dysfunction and nuclear-mitochondrial shuttling of TERT are involved in cell proliferation arrest induced by G-quadruplex ligands

2013-06-05

[FEBS Lett. 587(11) , 1656-62, (2013)]

Inhibition of mitochondrial and Paracoccus denitrificans NADH-ubiquinone reductase by oxacarbocyanine dyes. A structure-activity study.

1993-05-25

[Biochem. Pharmacol. 45(10) , 2115-22, (1993)]

Mix and measure fluorescence screening for selective quadruplex binders.

2008-10-01

[Nucleic Acids Res. 36 , e106, (2008)]

Interaction of certain cationic dyes with the respiratory chain of rat liver mitochondria.

1981-01-10

[J. Biol. Chem. 256(1) , 402-8, (1981)]

A G-quadruplex ligand 3,3'-diethyloxadicarbocyanine iodide induces mitochondrion-mediated apoptosis but not decrease of telomerase activity in nasopharyngeal carcinoma NPC-TW01 cells.

2004-01-01

[Pharm. Res. 21(1) , 93-100, (2004)]

More Articles...