International Journal of Tissue Reactions 1990-01-01

New ligands for human C-reactive protein: calcium-dependent binding with epsilon-aminocaproic acid-agarose and calcium-independent binding with omega-aminohexyl-agarose.

S Kuwajima, T Kishida, T Noda, Y Izumi, K Naka, T Matsui, K Okuda

Index: Int. J. Tissue React. 12(2) , 71-6, (1990)

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Abstract

Human C-reactive protein (CRP) is an acute phase protein which increases in concentration in response to inflammation. CRP has been known to bind with phosphorylcholine in a calcium-dependent manner. In this study, CRP is found to bind to affinity chromatography of negatively-charged epsilon-aminocaproic acid-agarose when calcium ions are present, and to the affinity chromatography of positively-charged omega-aminohexyl-agarose if a normal ionic strength of NaCl exists but calcium ion is not present.

Related Compounds

  • 6-Aminohexyl–Aga...

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