Tetrahedron Letters

Synthesis of 3-acylpyridines utilizing a friedel-crafts reaction

DL Comins, NB Mantlo

Index: Comins, Daniel L.; Mantlo, Nathan B. Tetrahedron Letters, 1983 , vol. 24, # 35 p. 3683 - 3686

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Citation Number: 42

Abstract

... SYNTHESIS OF 3-ACYLPYRIDINES UTILIZING A FRIEDEL-CRAFTS REACTION Daniel L. Comins* and Nathan B. Mantlo Department of Chemistry and Biochemistry ... The Friedel-Crafts acylation is an important method for the preparation of aryl ketones.l The reaction fails in the pyridine series however, and thus substituted 3acylpyridines are difficult to prepare.2 The failure of the Friedel-Crafts reaction with pyridines is due to the basicity of the ring nitrogen. ...