Synthetic Communications®

Convenient Method for the Preparation of Carboxylic Esters Using (Chloromethylene) dimethylammonium Chloride

H Nagao, M Michida, T Mukaiyama

Index: Nagao, Hitoshi; Michida, Makoto; Mukaiyama, Teruaki Synthetic Communications, 2008 , vol. 38, # 18 p. 3208 - 3214

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Citation Number: 7

Abstract

Abstract (Chloromethylene) dimethylammonium chloride (Vilsmeier reagent) works as an efficient condensation reagent in the formation of carboxylic esters from carboxylic acids and alcohols under mild conditions in a one-pot procedure. Secondary alcohols are converted successively into the corresponding esters in moderate to high yields with inversion of configurations.