A Mild, Efficient Approach for the Synthesis of 1, 5??Disubstituted Hydantoins

F Olimpieri, MC Bellucci, A Volonterio…

Index: Olimpieri, Francesca; Bellucci, Maria Cristina; Volonterio, Alessandro; Zanda, Mateo European Journal of Organic Chemistry, 2009 , # 35 p. 6179 - 6188

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Citation Number: 11

Abstract

Abstract An efficient and straightforward two-step procedure for the synthesis of N-1 alkyl/aryl-substituted hydantoins was developed, starting from easily available starting materials. The procedure envisages a highly regiospecific domino condensation/aza- Michael (nucleophilic substitution)/O [RIGHTWARDS ARROW] N acyl migration between activated α, β-unsaturated carboxylic acids or α-haloaryl acetic acids, respectively, and N- ...

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