Organic Letters 2014-07-03

Palladium-catalyzed formylation of aryl halides with tert-butyl isocyanide.

Xiao Jiang, Jin-Mei Wang, Ying Zhang, Zhong Chen, Yong-Ming Zhu, Shun-Jun Ji

Index: Org. Lett. 16(13) , 3492-5, (2014)

Full Text: HTML

Abstract

A novel palladium-catalyzed formylation of aryl halides with isocyanide in the presence of Et3SiH has been demonstrated, which provides a strategy toward important aldehydes with moderate to excellent yield. The advantage of this reaction includes milder conditions, convenient operation, lower toxicity, and wide functional group tolerance.

Related Compounds

  • Tert-Butyl isocya...

Related Articles:

Optimization of the Ugi reaction using parallel synthesis and automated liquid handling.

2008-01-01

[J. Vis. Exp. (21) , doi:10.3791/942, (2008)]

Palladium-catalyzed synthesis of isocoumarins and phthalides via tert-butyl isocyanide insertion.

2012-11-16

[J. Org. Chem. 77(22) , 10321-8, (2012)]

Towards molecular diversity: dealkylation of tert-butyl amine in Ugi-type multicomponent reaction product establishes tert-butyl isocyanide as a useful convertible isonitrile.

2010-08-21

[Org. Biomol. Chem. 8(16) , 3631-4, (2010)]

Strong carbon-surface dative bond formation by tert-butyl isocyanide on the Ge(100)-2 × 1 surface.

2014-04-23

[J. Am. Chem. Soc. 136(16) , 5848-51, (2014)]

Structural and spectroscopic studies of some copper(I) halide tert-butyl isocyanide adducts.

2008-04-07

[Dalton Trans. (13) , 1710-20, (2008)]

More Articles...