Tetrahedron letters

The accelerated development of an optimized synthesis of 1, 2, 4-oxadiazoles: application of microwave irradiation and statistical design of experiments

…, P Edwards, D Berthelot, R Nicewonger, CM Baldino

Index: Evans, Marc D.; Ring, Jessica; Schoen, Adam; Bell, Andrew; Edwards, Paul; Berthelot, Didier; Nicewonger, Robb; Baldino, Carmen M. Tetrahedron Letters, 2003 , vol. 44, # 52 p. 9337 - 9341

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Citation Number: 56

Abstract

Herein, we report the development of an optimized microwave-assisted synthesis of 1, 2, 4- oxadiazoles. The chemistry development process was significantly accelerated by employing a statistical software package (MODDE 6.0™) to guide in the optimization of the reaction conditions. The resulting optimized reaction conditions were then utilized in the synthesis of a focused library of 1, 2, 4-oxadiazoles.

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