Tetrahedron letters

DMF as a dimethylamine equivalent in the palladium-catalyzed nucleophilic substitution of naphthylmethyl and allyl acetates

M Toffano, JY Legros, JC Fiaud

Index: Toffano, Martial; Legros, Jean-Yves; Fiaud, Jean-Claude Tetrahedron Letters, 1997 , vol. 38, # 1 p. 77 - 80

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Citation Number: 30

Abstract

Naphthylmethyl acetates 1a and 2a were substituted by morpholine in DMPU in the presence of 2 mol% of [Pd (dba) 2+ 1.5 dppe] to give products 9–10 in 66–70% isolated yield. In DMF in the presence of benzylamine, N, N-dimethylnaphthylmethylamines 11–12 were produced in 78–85% isolated yield.

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