Bioorganic & Medicinal Chemistry 2004-10-15

Enantioselective syntheses of (R)- and (S)-argentilactone and their cytotoxic activities against cancer cell lines.

Angelo de Fatima, Luciana Konecny Kohn, Márcia Aparecida Antônio, João Ernesto de Carvalho, Ronaldo Aloise Pilli

Index: Bioorg. Med. Chem. 12(20) , 5437-42, (2004)

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Abstract

Concise total syntheses of (R)- and (S)-argentilactone have been developed via enantioselective catalytic allylation (ECA) and ring-closing metathesis pathways (four steps, 39% overall yield and 82-84% ee) from 2-octynal and their in vitro activity against cancer cells is described.