Highly Efficient Synthesis of Ureas and Carbamates from Amides by Iodosylbenzene??Induced Hofmann Rearrangement

P Liu, Z Wang, X Hu

Index: Liu, Peng; Wang, Zhiming; Hu, Xianming European Journal of Organic Chemistry, 2012 , # 10 p. 1994 - 2000

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Citation Number: 8

Abstract

Abstract A simple and efficient method for the synthesis of 1, 3-disubstituted ureas and carbamates from amides by using iodosylbenzene as the oxidant is described. Symmetric and asymmetric ureas and carbamates can be prepared by this procedure in up to 98% yield. Ureidopeptides can also be prepared in good yield by this method.