Biochemical and Biophysical Research Communications 2012-06-15

The anti-tumor effect of cross-reacting material 197, an inhibitor of heparin-binding EGF-like growth factor, in human resistant ovarian cancer

Xiao-han Tang, Suo Deng, Meng Li, Mei-song Lu

Index: Biochem. Biophys. Res. Commun. 422(4) , 676-80, (2012)

Full Text: HTML

Abstract

Highlights ► HB-EGF over-expression in A2780/Taxol, A2780/CDDP cells and the matched xenografts. ► CRM197 induces enhanced apoptosis in A2780/Taxol and A2780/CDDP cells. ► CRM197 arrests A2780/Taxol and A2780/CDDP cells at G0/G1 phase. ► CRM197 suppressed the A2780/Taxol and A2780/CDDP growth of xenografts.

Related Compounds

  • Diphtheria toxin...

Related Articles:

Carbohydrate-based vaccines with a glycolipid adjuvant for breast cancer.

2013-02-12

[Proc. Natl. Acad. Sci. U. S. A. 110(7) , 2517-22, (2013)]

Glycoconjugate vaccines and immune interactions, and implications for vaccination schedules.

2011-11-01

[Expert Rev. Vaccines 10(11) , 1621-31, (2011)]

Antitumor effects of CRM197, a specific inhibitor of HB-EGF, in T-cell acute lymphoblastic leukemia.

2011-07-01

[Anticancer Res. 31(7) , 2483-8, (2011)]

Effect of increased CRM₁₉₇ carrier protein dose on meningococcal C bactericidal antibody response.

2012-04-01

[Clin. Vaccine Immunol. 19(4) , 551-6, (2012)]

Immunization with the conjugate vaccine Vi-CRM₁₉₇ against Salmonella typhi induces Vi-specific mucosal and systemic immune responses in mice.

2012-09-21

[Vaccine 30(43) , 6111-4, (2012)]

More Articles...