The formation of cyclized silyl derivatives of beta-hydroxyamines and their analyses by means of gas chromatography mass spectrometry.

C G Hammar

Index: Biomed. Mass Spectrom. 5(1) , 25-8, (1978)

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Abstract

A generally applicable silylation method for beta-hydroxylated primary, secondary, tertiary and even quaternary amines is presented. These aminoalcohols form 6-membered heterocycles under the influence of a reagent mixture consisting of 1,3-bis-(chloromethyl)-1,1,3,3-tetramethyldisilazane and chloromethyldimethyl-chlorosilane. Examples of analogue ring closures with a gamma-hydroxyamine and an alpha-amino acid are also given. The formation of the derivatives and their properties, are discussed, mainly from the viewpoint mass spectrometry.