Nucleic Acids Symposium Series 1989-01-01

Conformational characteristics of 4-acetylcytidine found in tRNA.

G Kawai, T Hashizume, T Miyazawa, J A McCloskey, S Yokoyama

Index: Nucleic Acids Symp. Ser. (21) , 61-2, (1989)

Full Text: HTML

Abstract

The conformational characteristics of a modified nucleoside 4-acetylcytidine (ac4C) was analyzed by proton nuclear magnetic resonance spectroscopy. This nucleoside was found to take the C3'-endo form predominantly. The enthalpy difference between the C2'-endo form and the C3'-endo form of the ribose moiety of ac4C was determined and 4-acetylation was found to stabilize the C3'-endo form further by 0.83 kcal.mol-1. This conformational characteristics of ac4C is probably important for the correct codon recognition and the stability of the tertiary structure of tRNA molecule.

Related Compounds

  • N-Acetylcytidine

Related Articles:

Exometabolom analysis of breast cancer cell lines: Metabolic signature.

2015-01-01

[Sci. Rep. 5 , 13374, (2015)]

Least absolute shrinkage and selection operator and dimensionality reduction techniques in quantitative structure retention relationship modeling of retention in hydrophilic interaction liquid chromatography.

2015-07-17

[J. Chromatogr. A. 1403 , 54-62, (2015)]

The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression.

2013-06-01

[Nucleic Acids Res. 41(11) , 5669-78, (2013)]

Use of biological fluids for the rapid diagnosis of potentially lethal inherited disorders of human purine and pyrimidine metabolism.

1986-06-01

[Biomed. Chromatogr. 1(3) , 109-18, (1986)]

A quantitative systems approach reveals dynamic control of tRNA modifications during cellular stress.

2010-12-01

[PLoS Genet. 6 , e1001247, (2010)]

More Articles...