A novel electrophilic fluorination of activated aromatic rings using acetyl hypofluorite, suitable also for introducing fluorine-18 into benzene

O Lerman, Y Tor, D Hebel, S Rozen

Index: Lerman, Ori; Yitzhak, Tor; Hebel, David; Rozen, Shlomo Journal of Organic Chemistry, 1984 , vol. 49, p. 806 - 813

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Citation Number: 72

Abstract

Acetyl hypofluorite (1) is a new compound that serves as a novel electrophilic fluorinating agent. It is special in the sense that, while it is very reactive, it is still a milder reagent than other fluoroxy compounds such as CF30F or CF3COOF. It is synthesized directly from elemental fluorine and is used without any isolation or purification. The hypofluorite 1 reacts efficiently and selectively with activated aromatic rings, particularly phenol and aniline ...