Hydroxide??catalyzed synthesis of heterocyclic aromatic amine derivatives from nitriles

NR Smyrl, RW Smithwick

Index: Smyrl, Norman R.; Smithwick, Robert W. Journal of Heterocyclic Chemistry, 1982 , vol. 19, p. 493 - 496

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Citation Number: 26

Abstract

Abstract A generalized method for synthesizing a wide variety of heterocyclic aromatic amine derivatives from nitriles by use of hydroxide catalysts is presented. Nitrile dimers (3- aminocrotononitrile and dicyandiamide) and a dimer analog (anthranilonitrile) react with monomeric nitriles in the presence of hydroxide to form respectively, aminopyrimidines, diaminotriazines and aminoquinazolines.