Brain levels and metabolism of the dopaminergic agonist 2-amino-6, 7-dihydroxytetrahydronaphthalene after administration of various prodrugs
AS Horn, H Griever-Kazemier…
Index: Horn, A. S.; Griever-Kazemier, H.; Dijkstra, D. Journal of Medicinal Chemistry, 1982 , vol. 25, # 8 p. 993 - 996
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Citation Number: 13
Abstract
Results In the DA-rich corpus striatum (Figure l), the 6, 7-ADTN time-concentration curves can be clearly divided into two groups, ie, those arising from the diacetyl and diisobutyryl derivatives, which produced rapid peak concentrations in the first 5-15 min, and the dibenzoyl and dipivaloyl analogues, which gave peak levels at 3 h and generally resulted in plateau-like levels over many hours. A somewhat similar effect was seen in the ...
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