Synthetic Communications

Saccharin as an Organocatalyst for Quinoxalines and Pyrido [2, 3-b] pyrazines Syntheses

F Lassagne, F Chevallier, F Mongin

Index: Lassagne, Frederic; Chevallier, Floris; Mongin, Florence Synthetic Communications, 2014 , vol. 44, # 1 p. 141 - 149

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Citation Number: 4

Abstract

A room-temperature procedure using saccharin as catalyst has been described for the cyclocondensation of different 1,2-arylenediamines with various 1,2-dicarbonyl compounds, yielding either quinoxalines or pyrido[2,3-b]pyrazines. The reactions proceed in very short reaction times in methanol, and the target heterocycles are isolated in quantitative yields after addition of water, filtration, and drying. Substituted pyrido[2,3-b]pyrazines can also be reached regioselectively by ...

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