Tetrahedron Letters

Microwave-assisted synthesis of azetidines in aqueous media

BA Burkett, SZ Ting, GCS Gan, CLL Chai

Index: Burkett, Brendan A.; Ting, Samuel Z.; Gan, Gwendolyn C. S.; Chai, Christina L. L. Tetrahedron Letters, 2009 , vol. 50, # 47 p. 6590 - 6592

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Citation Number: 8

Abstract

Simple azetidines are synthesized in good to excellent yields and high purity via cyclization of 3-(ammonio) propyl sulfates derived from primary amines and the cyclic sulfate of 1, 3- propanediol. A feature of this methodology includes the accelerated synthesis of azetidines in water under the influence of microwave-assisted heating.