Chemical & Pharmaceutical Bulletin 2003-03-01

Highly-oxygenated isopimarane-type diterpenes from Orthosiphon stamineus of Indonesia and their nitric oxide inhibitory activity.

Suresh Awale, Yasuhiro Tezuka, Arjun H Banskota, I Ketut Adnyana, Shigetoshi Kadota

Index: Chem. Pharm. Bull. 51(3) , 268-75, (2003)

Full Text: HTML

Abstract

From the methanolic extract of Indonesian Orthosiphon stamineus, nine new highly-oxygenated isopimarane-type diterpenes [7-O-deacetylorthosiphol B (1), 6-hydroxyorthosiphol B (2), 3-O-deacetylorthosiphol I (3), 2-O-deacetylorthosiphol J (4), siphonols A-E (5-9)] have been isolated together with nine known diterpenes [orthosiphols H (10), K (11), M (12) and N (13); staminols A (14) and B (15); neoorthosiphols A (16) and B (17); norstaminol A (18)]. Their structures were determined based on the spectroscopic data. The isolated diterpenes inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-activated macrophage-like J774.1 cells. Compounds 4-7, 9, 10, 14, and 17 showed inhibitory activities more potent (IC(50), 10.8-25.5 microM) than a positive control N(G)-monomethyl-L-arginine (L-NMMA; IC(50), 26.0 microM).

Related Compounds

  • (5ξ,9ξ,13α)-Pimara...

Related Articles:

Phloroglucinols from anti-microbial deposit-resins of Australian stingless bees (Tetragonula carbonaria).

2015-01-01

[Phytother Res. 29(1) , 48-58, (2015)]

Spontaneous and evoked contractions are regulated by PKC-mediated signaling in detrusor smooth muscle: involvement of BK channels.

2013-03-01

[Am. J. Physiol. Renal Physiol. 304(5) , F451-62, (2013)]

[Analysis of main chemical composition in hydrogenated rosin from Zhuzhou].

2001-01-01

[Se Pu 19(1) , 78-81, (2001)]

Influence of band 3 protein absence and skeletal structures on amphiphile- and Ca(2+)-induced shape alterations in erythrocytes: a study with lamprey (Lampetra fluviatilis), trout (Onchorhynchus mykiss) and human erythrocytes.

2000-06-01

[Biochim. Biophys. Acta 1466(1-2) , 125-38, (2000)]

Pseudomonas reinekei sp. nov., Pseudomonas moorei sp. nov. and Pseudomonas mohnii sp. nov., novel species capable of degrading chlorosalicylates or isopimaric acid.

2007-05-01

[Int. J. Syst. Evol. Microbiol. 57(Pt 5) , 923-31, (2007)]

More Articles...