Intramolecular Acylation. II. 1 The Inverse Friedel--Crafts Method

WS Johnson, HJ Glenn

Index: Johnson; Glenn Journal of the American Chemical Society, 1949 , vol. 71, p. 1092,1095

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Citation Number: 20

Abstract

Of the numerous methods available for effecting ring closure of p-arylpropionic or y- arylbutyric acid derivatives to cyclic ketones, the intramolecular Friedel-Crafts reaction of the acid chloride with aluminum chloride promises to be particularly useful for acids like pp- methoxyphenylpropionic acid, which are resistant to cyclization due to unfavorable reactivity of the aromatic nucleus. Excellent yields have not been generally realized by this method, ...