Journal of Surgical Research 2011-07-01

Azelnidipine, a new calcium channel blocker, promotes skin wound healing in diabetic rats.

Mansooreh Bagheri, Behnam Moein Jahromi, Hossein Mirkhani, Zhabiz Solhjou, Ali Noorafshan, Ali Zamani, Zahra Amirghofran, Mansooreh Bagheri, Behnam Moein Jahromi, Hossein Mirkhani, Zhabiz Solhjou, Ali Noorafshan, Ali Zamani, Zahra Amirghofran

Index: J. Surg. Res. 169(1) , e101-7, (2011)

Full Text: HTML

Abstract

Impaired wound healing in diabetes is associated with decreased nitric oxide (NO) bioavailability in wound tissue. We hypothesized azelnidipine (AZL), a new calcium channel blocker with antioxidant properties, would enhance wound healing in streptozotocin-induced diabetic rats by restoring NO synthesis.Twelve male rats were taken as non-diabetic group. Twenty four rats were taken and caused to be diabetic by a single streptozotocin injection. Diabetic rats were divided randomly to two groups: control and treatment. Half of non-diabetic and also diabetic rats (in each group of control and treatment) randomly served as excisional-wound model and the other half as nitrite-measurement model. Six weeks after causing diabetes, the excisional wound model underwent dorsal full-thickness excisional wounds (1 × 1 cm). After wound healing completion, full-thickness skin samples (1 × 1 cm) were taken from the wound sites for evaluation of stereological parameters. The nitrite-measurement model (6 wk after causing diabetes) underwent insertion of subcutaneous polyvinyl alcohol sponges in dorsum. The rats were killed 2 wk post-wounding, and wound fluid was analyzed. In the study, after wounding, the treatment groups were gavaged with AZL (3 mg/kg/d) and control and non-diabetic groups with AZL vehicle till euthanasia.AZL accelerated wound healing rate and also improved wound fluid NO level toward normal value in diabetic rats. Volume density of collagen fibers, numerical density of fibroblasts, and length density of vessels were increased in AZL-treated rats compared with control group.AZL administration promotes diabetic wound healing by stimulating NO production and enhancing histologic processes central to normal wound healing.Copyright © 2011 Elsevier Inc. All rights reserved.

Related Compounds

  • Azelnidipine

Related Articles:

Anti-atherogenic effects of the combination therapy with olmesartan and azelnidipine in diabetic apolipoprotein E-deficient mice.

2012-01-01

[Tohoku J. Exp. Med. 228 , 305-315, (2012)]

The pharmacological differences in antianginal effects of long-lasting calcium channel blockers: azelnidipine and amlodipine.

2013-01-01

[J. Cardiovasc. Pharmacol. 61(1) , 63-9, (2013)]

Azelnidipine prevents cardiac dysfunction in streptozotocin-diabetic rats by reducing intracellular calcium accumulation, oxidative stress and apoptosis.

2011-01-01

[Cardiovasc. Diabetol. 10 , 97, (2011)]

Effects of calcium channel blockers on glucose tolerance, inflammatory state, and circulating progenitor cells in non-diabetic patients with essential hypertension: a comparative study between azelnidipine and amlodipine on glucose tolerance and endothelial function--a crossover trial (AGENT).

2011-01-01

[Cardiovasc. Diabetol. 10 , 79, (2011)]

Additive antioxidative effects of azelnidipine on angiotensin receptor blocker olmesartan treatment for type 2 diabetic patients with albuminuria.

2011-08-01

[Hypertens. Res. 34(8) , 935-41, (2011)]

More Articles...