Bioorganic & Medicinal Chemistry Letters 2007-04-01

Design and synthesis of beta-methoxyacrylate analogues via click chemistry and biological evaluations.

Hao Chen, Janet L Taylor, Suzanne R Abrams

Index: Bioorg. Med. Chem. Lett. 17 , 1979-83, (2007)

Full Text: HTML

Abstract

A library of potential antifungal triazole-modified beta-methoxyacrylate analogues was designed and synthesized via a Cu(I)-catalyzed 1,3-dipolar alkyne-azide coupling reaction or 'click chemistry'. Subsequent biological screening revealed that some compounds displayed low to moderate antifungal activity toward pathogenic fungi and low phytotoxicity.

Related Compounds

  • Ethynyl 4-methylph...

Related Articles:

Tosvinyl and besvinyl as protecting groups of imides, azinones, nucleosides, sultams, and lactams. Catalytic conjugate additions to tosylacetylene.

2014-09-19

[J. Org. Chem. 79(18) , 8826-34, (2014)]

Efficient and practical method for synthesizing optically active indan-2-ols by the Ti(O-i-Pr)(4)/2 i-PrMgCl-mediated metalative Reppe reaction.

2003-06-13

[J. Org. Chem. 68(12) , 4980-3, (2003)]

A Simplified Method for the Preparation of Ethynyl P-Tolyl Sulfone and Ethynyl Phenyl Sulfone. Chen Z and Trudell ML.

[Synth. Commun. 24(21) , 3149-55, (1994)]

More Articles...