FEBS Letters 1993-01-04

Loss of alpha-tocopherol upon exposure to nitric oxide or the sydnonimine SIN-1.

H de Groot, U Hegi, H Sies

Index: FEBS Lett. 315 , 139-142, (1993)

Full Text: HTML

Abstract

SIN-1 which spontaneously decomposes to yield nitric oxide (NO.) and superoxide anion (O2.-) radicals caused a loss of microsomal alpha-tocopherol paralleled by the formation of alpha-tocopheryl quinone. The loss was partially prevented by superoxide dismutase but not by catalase. The SIN-1-induced loss of alpha-tocopherol also occurred when tocopherol was dissolved in ethanol/potassium phosphate buffer (20/80, v/v). Likewise, addition of authentic NO. to alpha-tocopherol dissolved in ethanol resulted in loss of the vitamin and quinone formation. These results suggest that NO. or its products such as peroxynitrite or nitrogen dioxide react with alpha-tocopherol, the quinone derivative being a major oxidation product. Depletion of vitamin E by NO. may contribute to tissue injury, e.g. in neuronal tissues.

Related Compounds

  • Linsidomine hydroc...

Related Articles:

Activated platelets rescue apoptotic cells via paracrine activation of EGFR and DNA-dependent protein kinase.

2014-01-01

[Cell Death Dis. 5 , e1410, (2014)]

Taurine reduces nitrosative stress and nitric oxide synthase expression in high glucose-exposed human Schwann cells.

2012-01-01

[Exp. Neurol. 233(1) , 154-62, (2012)]

Comparative kinetics of thiol oxidation in two distinct free-radical generating systems: SIN-1 versus AAPH.

2012-10-01

[Free Radic. Res. 46(10) , 1190-200, (2012)]

Conformational altered p53 as an early marker of oxidative stress in Alzheimer's disease.

2012-01-01

[PLoS ONE 7(1) , e29789, (2012)]

Peroxynitrite donor SIN-1 alters high-affinity choline transporter activity by modifying its intracellular trafficking.

2012-04-18

[J. Neurosci. 32(16) , 5573-84, (2012)]

More Articles...