Organomanganese (II) reagents XII: An efficient one-pot preparation of unsymmetrical secondary or tertiary alcohols

G Cahiez, J Rivas-Enterrios, H Granger-Veyron

Index: Cahiez, G.; Rivas-Enterrios, J.; Granger-Veyron, H. Tetrahedron Letters, 1986 , vol. 27, # 37 p. 4441 - 4444

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Citation Number: 16

Abstract

Abstract Various unsymmetrical secondary or tertiary alcohols have been prepared in high yields by an efficient one-pot procedure involving the acylation of an organomanganese reagent by an acyl chloride and addition to the ketone formed of various organometallic compounds (RLi, RmgX, LiAlH 4, NaBH 4. The complexation of the intermediate ketone by the metallic salts present in the reaction mixture allows to perform the 1–2 addition step ...