Archives of Pharmacal Research 2003-11-01

Synthesis and antiviral activity of novel trans-2,2-dimethyl cyclopropyl nucleosides.

Min Chul Kook, Bo Gil Choi

Index: Arch. Pharm. Res. 26(11) , 887-91, (2003)

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Abstract

Novel trans-2,2-dimethylcyclopropyl nucleosides were synthesized as potential antiviral agents. The key intermediate, 3, was synthesized via five steps from ethyl chrysanthemate and condensed with purine bases using the Mitsunobu reaction to give six cyclopropyl nucleosides. These synthesized nucleosides did not show any significant antiviral activity against HSV-1, HSV-2, EMCV, Cox B3, or VSV, at concentrations up to 100 microM.

Related Compounds

  • Ethyl chrysanthema...

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