Synthesis of N-Phosphorylated Derivatives of Nitrogen Mustards with Latent Cytotoxicity1

OM Friedman, E Boger, V Grubliauskas…

Index: Friedman,O.M. et al. J. Med. Chem., 1963 , vol. 6, p. 50 - 58

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Citation Number: 38

Abstract

The phosphoramide nitrogen niiietards reported iiiclude series of phosphoro-trianiides, diainidic esters, amidic diesters, diamidic acids, ester amidic acids and sZ/t, 1-i) Srophosphoro~ iai~ iidic diesters that were synthesized because of their possible selective action against tumors. Some of t'hese compounds already tested in experimental animals have shown significant antitumor activity.