Eukaryotic Cell 2003-10-01

Neutral-lipid analysis reveals elevation of acylglycerols and lack of cholesterol esters in Plasmodium falciparum-infected erythrocytes.

Parwez Nawabi, Athanasios Lykidis, Darder Ji, Kasturi Haldar

Index: Eukaryotic Cell 2(5) , 1128-31, (2003)

Full Text: HTML

Abstract

Here we show that blood-stage Plasmodium falciparum organisms accumulate a high mass of triacylglycerol and diacylglycerol. However, we failed to detect cholesterol esters, a second neutral lipid species reported to be important for a related apicomplexan, Toxoplasma gondii. Evidence for P. falciparum and T. gondii homologues of acyl coenzyme A:diacylglycerol acyltransferase suggests that acylglycerols may be the conserved neutral lipids in apicomplexans.

Related Compounds

  • Sandoz 58-035

Related Articles:

An LXR-NCOA5 gene regulatory complex directs inflammatory crosstalk-dependent repression of macrophage cholesterol efflux.

2015-05-05

[EMBO J. 34 , 1244-58, (2015)]

Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus.

2014-09-01

[Arthritis Rheumatology 66(9) , 2532-44, (2014)]

Lipid droplet changes in proliferating and quiescent 3T3 fibroblasts.

2008-05-01

[Histochem. Cell Biol. 129(5) , 611-21, (2008)]

DAMP, an acidotropic pH indicator, can be used as a tool to visualize non-esterified cholesterol in cells.

2015-02-01

[Acta Biochim. Biophys. Sin. (Shanghai) 47(2) , 73-9, (2015)]

Mitotane Inhibits Sterol-O-Acyl Transferase 1 Triggering Lipid-Mediated Endoplasmic Reticulum Stress and Apoptosis in Adrenocortical Carcinoma Cells.

2015-11-01

[Endocrinology 156 , 3895-908, (2015)]

More Articles...