Benzophenone-and Indolecarboxylic Acids: Potent Type-2 Specific Inhibitors of Human Steroid 5. alpha.-Reductase

…, AL Konialian-Beck, JI Luengo, AD Abell…

Index: Holt, Dennis A.; Yamashita, Dennis S.; Konialian-Beck, Arda L.; Luengo, Juan I.; Abell, Andrew D.; et al. Journal of Medicinal Chemistry, 1995 , vol. 38, # 1 p. 13 - 15

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Citation Number: 54

Abstract

Dihydrotestosterone (DHT), a metabolite of the predominant circulating androgen testosterone (T), is recognized as a principal mediator of benign prostatic hyperplasia (BPH), an ailment aMicting a remarkably large percentage of aging ma1es. l DHT also has been implicated in the etiology of prostatic cancer2 and several disorders of the skin including acne, 3 androgenic al~ pecia,~ and hir~ utism.~ As a consequence, a search has ensued ...

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