Journal of Pharmaceutical and Biomedical Analysis 2002-01-15

Comparative study of the enantiomeric resolution of chiral antifungal drugs econazole, miconazole and sulconazole by HPLC on various cellulose chiral columns in normal phase mode.

Hassan Y Aboul-Enein, Imran Ali

Index: J. Pharm. Biomed. Anal. 27(3-4) , 441-6, (2002)

Full Text: HTML

Abstract

The chiral resolution of (+/-)-econazole, (+/-)-miconazole and (+/-)-sulconazole on the columns containing different cellulose derivatives namely Chiralcel OD, OJ, OB, OK, OC and OF in normal phase mode has been described. The mobile phase used was hexane-2-propanol-diethylamine (425:74:1, v/v/v). The flow rates of the mobile phase used were 0.50, 1.00 and 1.50 ml/min. The values of the separation factor (alpha) of the resolved enantiomers of econazole, miconazole and sulconazole on chiral phases were ranged from 1.07 to 2.50 while the values of resolution factor (R(s)) varied from 0.17 to 3.90. The chiral recognition mechanisms between the analytes and the chiral selectors are discussed.

Related Compounds

  • Sulconazole mononi...

Related Articles:

Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column.

2005-08-12

[J. Chromatogr. A. 1083(1-2) , 133-40, (2005)]

Athlete's foot.

2005-12-01

[Clin. Evid. (14) , 2000-5, (2005)]

Direct lethal action of sulconazole and butoconazole.

1991-01-01

[Ann. Dermatol. Venereol. 118 Suppl 1 , 5-6, (1991)]

In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.

1992-04-01

[Mycopathologia 118(1) , 15-21, (1992)]

Enantioselective addition of thioacetic acid to nitroalkenes via N-sulfinyl urea organocatalysis.

2009-07-01

[J. Am. Chem. Soc. 131(25) , 8754-5, (2009)]

More Articles...