Bioorganic & Medicinal Chemistry Letters 2009-02-15

Discovery and SAR of para-alkylthiophenoxyacetic acids as potent and selective PPARdelta agonists.

Rui Zhang, Alan Deangelis, Aihua Wang, Ellen Sieber-McMaster, Xun Li, Ronald Russell, Patricia Pelton, Jun Xu, Peifang Zhu, Lubing Zhou, Keith Demarest, William V Murray, Gee-Hong Kuo

Index: Bioorg. Med. Chem. Lett. 19(4) , 1101-4, (2009)

Full Text: HTML

Abstract

Synthesis and SAR of para-alkylthiophenoxyacetic acids is described. Achiral compounds 30, 31 and 32 were identified as potent and selective PPARdelta agonists.

Related Compounds

  • Phenyl thioacetic...

Related Articles:

Density functional theory calculations of structure, FT-IR and Raman spectra of S-phenyl thioacetate.

2011-10-15

[Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 81(1) , 236-41, (2011)]

Evaluation of a rapid differentiation test for the Mycobacterium tuberculosis complex by selective inhibition with rho-nitrobenzoic acid and thiophene-2-carboxylic acid hydrazide.

2005-02-01

[Int. J. Tuberc. Lung Dis. 9(2) , 206-9, (2005)]

Identification of two rat liver proteins with paraoxonase activity: biochemical evidence for the identity of paraoxonase and arylesterase.

1999-05-14

[Chem. Biol. Interact. 119-120 , 263-75, (1999)]

Reactivity of cyclic sulfamidates towards sulfur-stabilised enolates. Stereocontrolled synthesis of functionalised lactams.

2006-05-21

[Org. Biomol. Chem. 4(10) , 1868-77, (2006)]

Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase.

2007-01-01

[Biochim. Biophys. Acta 1774(1) , 16-34, (2007)]

More Articles...